advan8 vs. advan13
Hello NONMEM users,
Because advan13 was recomended for both stiff and nonstiff differential
equations, I used it for stiff differential equations. It appeared that some
results looked too sensitive to a parameters representing a "slow" processes.
I did not observe it with nonmem6. When I used advan8, the objective function
changed from 10228.853 (the final value; diagnostic plots looked good) to
5512.594 (the first value; I im still waiting for the final value of the
objective function).
Does it mean that advan13 should be used with caution when the equations are
stiff or advan13 cannot replace advan8?
Thanks,
Pavel