Re: Asterisks in simulated data after changes to maximum observation records and BUFFER
Many thanks to Dick Brundage for checking my code and data file. It
appears that my NONMEM installation became corrupted when I re-compiled
it after modifying the NObs and Buffers. I thought this not to be the
case because the installation ran the CONTROL3 theophylline case
without problems. Thanks to Dennis Fisher as well for his suggestion
that the asterisks are from extremely small values. I still don't know
if that was the case, or if there was some other issue that caused it.
He also points out that EXCEL can handle my 68,000 lines of simulated
data - I should have been more specific that it was the charting
function limit, for which there are of course other options.
Paul
Paul Hutson wrote:
I am attempting to generate 100 iterations of a
concentration curve for
multiple doses in a single individual.
In order to reflect the input of the extended release dosage form from
the dissolution data, I have multiple infusions into the gut
representing the amount released in each of these units of time based
on the dissolution data. For 14 doses, then, I am reproducing this,
and the data file is quite long (687 records). I have therefore had to
increase NSIZES with respect to the number of observations, as well as
increasing buffers 1,2, and 6.
I will need to import the results into R, since excel can't take
687X100 lines of output. However, regardless of whether I look at my
.txt output, or importing it as far as I can into Excel, the output
includes asterisks
ID TIME CMPT IPRE DV PRED RES WRES
1.0000E+00 0.0000E+00 1.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00
1.0000E+00 2.5000E-01 2.0000E+00 1.1193E-05 -5.6330E-02
3.0897E-05 -5.6361E-02 0.0000E+00
1.0000E+00 2.5000E-01 3.0000E+00 3.6747E-09 3.6747E-09
1.0143E-08 -6.4683E-09 0.0000E+00
1.0000E+00 2.5000E-01 1.0000E+00 1.1193E-05 0.0000E+00
3.0897E-05 0.0000E+00 0.0000E+00
1.0000E+00 5.0000E-01 2.0000E+00 *********** ***********
*********** *********** 0.0000E+00
1.0000E+00 5.0000E-01 3.0000E+00 *********** ***********
*********** *********** 0.0000E+00
Can anyone explain why I am getting the asterisks in the output (even
with only one simulation? Everything was fine before I messed with
the buffers (relevant part of SIZES below):
C NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD
C IF NO IS CHANGED, ALSO RECOMPILE NM-TRAN, NM-TRAN LIBRARY
PARAMETER (NOu0)
...
C LIM1: SIZE OF BUFFER 1
PARAMETER (LIM10)
C LIM2: SIZE OF BUFFER 2
PARAMETER (LIM20)
C LIM3: SIZE OF BUFFER 3
PARAMETER (LIM3 0)
C LIM4: SIZE OF BUFFER 4
PARAMETER (LIM4P)
C LIM5: SIZE OF BUFFER 5
PARAMETER (LIM5 0)
C LIM6: SIZE OF BUFFER 6
PARAMETER (LIM60)
C LIM7: SIZE OF BUFFER 7
PARAMETER (LIM7=2)
C LIM8: SIZE OF BUFFER 8
PARAMETER (LIM8 0)
C LIM11: SIZE OF BUFFER 11
PARAMETER (LIM11%)
C LIM13: SIZE OF BUFFER 13
PARAMETER (LIM13=1)
C LIM15: SIZE OF BUFFER 15
PARAMETER (LIM15=1)
C LIM16: SIZE OF BUFFER 16
PARAMETER (LIM16@0)
Thanks very much
Paul
--
Paul R
Paul R.
Hutson, Pharm.D.
Associate
Professor
UW School
of Pharmacy
777
Highland Avenue
Madison
WI 53705-2222
Tel 608.263.2496
Fax
608.265.5421
Pager
608.265.7000, p7856
--
Paul R
Paul R.
Hutson, Pharm.D.
Associate
Professor
UW School
of Pharmacy
777
Highland Avenue
Madison
WI 53705-2222
Tel 608.263.2496
Fax
608.265.5421
Pager
608.265.7000, p7856