Re: Steady state model
Hi Sherwin,
As Nick said, Alison would be the best source fro details, but I can give you the basic idea of what's done. For the constant rate input case, the solution is obtained as Nick described. In the case of multiple dosing with equal doses and dosing intervals, it is a root- finding problem that iteratively seeks a vector of values for the initial amounts in the compartments. The solution is the set of values such that the initial and final (end of dosing interval) values are equal for all compartments.
Bill
Quoted reply history
On Aug 5, 2009, at 2:44 PM, Sherwin K Sy wrote:
> Dear NONMEM users,
>
> I'm wondering what equation or ODE is used in NONMEM when the steady state is set (i.e. SS = 1). Is it the case that the initial parameter for the compartment is set to a different value? If so, how does NONMEM set this value?
>
> I would appreciate if anyone can provide me with a reference or point me to where I can find this information, including the type of equation used for extravascular, iv bolus and iv infusion models.
>
> Thanks,
>
> Sherwin