RE: covariance step

-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Varsha Mehta Sent: Thursday, July 16, 2009 1:21 PM To: [email protected]; [email protected] Subject: [NMusers] covariance step Dear NONMEM users: I have a data set for 30 infants where I am running a 2 COMPT PK model. I got the following error message for the covariance step. I need some help with trying to fix this error. Any suggestions? should I increase the upper boundries of initial estimates? MINIMIZATION SUCCESSFUL NO. OF FUNCTION EVALUATIONS USED: 289 NO. OF SIG. DIGITS IN FINAL EST.: 3.0 0PARAMETER ESTIMATE IS NEAR ITS BOUNDARY THIS MUST BE ADDRESSED BEFORE THE COVARIANCE STEP CAN BE IMPLEMENTED any help is appreciated. Thanks Varsha Mehta, MS(CRDSA), Pharm.D., FCCP Clinical Associate Professor Pharmacy, Pediatrics and Communicable Diseases Clinical Pharmacist Neonatal Critical Care University of Michigan (O) 734-936-8985 (F) 734-936-6946 [email protected] ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates (which may be known outside the United States as Merck Frosst, Merck Sharp & Dohme or MSD and in Japan, as Banyu - direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.