RE: Schwartz formulae

Nick This is just to express some objection to your last sentence below: > In children with more or less normal renal function > the Schwartz predicted CLcr is 30% greater than > concurrently measured inulin clearance > (a 'gold standard' GFR estimation method). > This is different from adults > in whom GFR and CLcr are very similar. Actually in adults, CLcr also overestimates by 20-40% the true GFR, as creatinine undergoes tubular secretion in addition to glomerular filtration (the inhibition of organic cation transporters is able to bring creatinine clearance near to inulin clearance). In a recent study, we found average 34% to 39% differences between both clearances in healthy volunteers, in line with others. (Tschuppert Y & al. Effect of dronedarone on renal function in healthy subjects. BJCP 2007; 64(6):785-791) Kind regards Thierry PD Dr Thierry Buclin Division of clinical Pharmacology and Toxicology Departement of Médecine, University Hospital of Lausanne (CHUV) Hôpital Beaumont 633 1011 Lausanne tel. +41 21 314 42 60 fax. +41 21 314 42 66