RE: Simultaneous vs sequential for modeling parent AND metabolites in pop PK
The argument against the simultaneous approach is that the PD data can
"drive" the PK model, particulary since the PD data usually has more
variability.
Quoted reply history
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Xiao, Alan
Sent: Tuesday, December 09, 2008 11:02 AM
To: [email protected]
Subject: [NMusers] Simultaneous vs sequential for modeling parent AND
metabolites in pop PK
Dear All,
I know this is an old topic but would like to see the statistics.
When you have to develop a pop PK model for both parent and active
metabolites, which approach do you prefer or have you used most:
simultaneous or sequential? Which way do you think is more scientific? I
heard comments saying that the simultaneous approach is not scientific.
Thanks,
Alan