RE: NONMEM message

> -----Original Message----- > From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] > On Behalf Of Higashimori, Mitsuo > Sent: den 13 november 2008 06:27 > To: Nick Holford; nmusers > Subject: RE: [NMusers] NONMEM message > > Dear Nick, > > Thank you for your advice. > In my case, covariance matrix also was displayed without any problem. So, > I could check whether covariance matrix is reasonable or not, but it was > difficult to interpret it for me. Therefore, I wanted to know if this > message is important. In addition, I mused if such a result should be > excluded from listing and summarizing the result files after bootstrap. > > Best regards, > Mitsuo > > > > -----Original Message----- > > From: [EMAIL PROTECTED] > > [mailto:[EMAIL PROTECTED] Behalf Of Nick Holford > > Sent: Thursday, November 13, 2008 1:58 PM > > To: nmusers > > Subject: Re: [NMusers] NONMEM message > > > > > > Mitsuo, > > > > This is a special kind of NONMEM error message: > > > > MINIMIZATION SUCCESSFUL > > HOWEVER, PROBLEMS OCCURRED WITH THE MINIMIZATION. > > REGARD THE RESULTS OF THE ESTIMATION STEP CAREFULLY, AND > > ACCEPT THEM ONLY > > AFTER CHECKING THAT THE COVARIANCE STEP PRODUCES REASONABLE OUTPUT. > > > > because the message itself seems to be an error. > > > > Whenever I see this message the covariance step does not run > > therefore I > > cannot decide if the covariance step produces reasonable output. I > > therefore ignore this message after the word SUCCESSFUL. > > > > The numerical oddities in NONMEM are well known so I am not surprised > > that raising women to a power make them have a different > > influence from > > distinguishing them explicitly from men. The power approach is > > computationally much less efficient than a conditional > > expression so I > > never use it if I can avoid it. > > > > Nick > > > > Higashimori, Mitsuo wrote: > > > Dear all, > > > > > > I have a following error(?) massage on a poplation analysis > > using NONMEM VI. > > > > > > 0MINIMIZATION SUCCESSFUL > > > HOWEVER, PROBLEMS OCCURRED WITH THE MINIMIZATION. > > > REGARD THE RESULTS OF THE ESTIMATION STEP CAREFULLY, AND > > ACCEPT THEM ONLY > > > AFTER CHECKING THAT THE COVARIANCE STEP PRODUCES REASONABLE OUTPUT. > > > > > > I found it when I described a control stream to assess sex > > difference on oral clearance as shown in below, > > > > > > TVCL = THETA(1) * THETA(2) ** SEX > > > where SEX=0 for male and SEX=1 for female. > > > > > > This message was displayed without any error message. It > > was not dissapeared even though I changed the initial > > parameters. However, it was solved when I changed the model > > definition. For example, > > > > > > TVCL = THETA(1) > > > IF (SEX.EQ.1) TVCL = THETA(2) > > > > > > Could you please let me know some details regarding the > > message. Especially, I'd like to know > > > > > > 1. What impact does this error message give the analysis result? > > > 2. Why does it depend on the model definition? > > > > > > Thanks, > > > > > > _/ _/ _/ Mitsuo Higashimori, Ph.D. > > > _/ _/ _/ Pharmacokinetic Group, Early Phase Development Department > > > _/ _/ _/ Clinical Division, Research & Development > > > _/ _/ _/ AstraZeneca K.K. > > > _/ _/ _/ E-mail: [EMAIL PROTECTED] > > > > > > > > > > > > > > > > -- > > Nick Holford, Dept Pharmacology & Clinical Pharmacology > > University of Auckland, 85 Park Rd, Private Bag 92019, > > Auckland, New Zealand > > [EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090 > > http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford > > > >