RE: unbalanced design
Hi Mark,
This should be true just based on the nature of mixed effects modeling.
If you are not convinced, you may want to try some examples where you
simulate balanced and unbalanced designs and then estimate. :-)
Best Regards,
Susan
Quoted reply history
________________________________
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Mark Sale - Next Level Solutions
Sent: Tuesday, September 02, 2008 1:28 PM
To: [email protected]
Subject: [NMusers] unbalanced design
Does anyone have a reference to a publication assessing whether mixed
effect modeling (NONMEM in particular) is robust for unbalances studies?
I see if in a number of courses (including the original beginners course
for NONMEM), but can't find a publication.
thanks
Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185