Re: Subpopulation
Huali
The best solution is to fit all of your data to the more general model.
In this case that is of course the non linear model
(the pk linear model is a simplification of the limit where cc is very small
relative to Km)
Saik
----- Original Message -----
Quoted reply history
From: Huali Wu
To: [email protected]
Sent: Tuesday, August 12, 2008 6:14 PM
Subject: [NMusers] Subpopulation
Dear NMusers:
I am trying to fit a dataset with 13 dose levels. The highest dose is about
10 times of the lowest dose. Each patient receive one dose and were sampled
intensively up to 7 days. The results of individual PK analysis shown linear
kinetics for some of the patients and nonlinear kinetics for the other
patients. I have tried to fit all of them together. But my advisor wants me to
fit linear patients and nonlinear patients separately to get a better look of
fitting.
Additionally, all the nonlinear patients are from higher dose levels. But not
all the patients in higher dose levels shown nonlinear kinetics. So my question
is which way is more appropriate in this case? Should I fit them all together
or separately? Could these two types of patients be considered as
subpopulations?
Any comment or suggestion will be highly appreciated.
Best regards,
Huali