Re: enzyme auto inhibition PK model

You will probably have to write your own model. One suggested model would be: V = Vmax x S/[Km + S x (1 + S/Ki)] Where V = velocity, S = substrate concentration, km = substrate concentration at half maximal velocity ki = inhibition constant Vmax = maximal velocity See: Mutlib AE GT, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S. Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity. Chem Res Toxicol. 2006;19(5):701-709. Regards David At 09:06 a.m. 6/6/2008, Yuyan Jin wrote: > Hi Dear Nonmem user, > > I am trying to model the kinetics of a compound that exhibits enzyme auto-inhibition.I have found some previously suggested literature by nonmem users, but all of them were auto-induction cases. Does anyone know any enzyme auto-inhibition PK model paper published ? > > Thanks so much! > > Sincerely, > Yuyan Jin > Graduate student > University of Pittsburgh Dr David Reith MBBS FRACP MMedSc(Pharm) PhD Associate Professor Dunedin School of Medicine University of Otago New Zealand Phone: +64 3 4740999 Fax: +64 3 4747817