enzyme auto inhibition PK model
Hi Dear Nonmem user,
I am trying to model the kinetics of a compound that exhibits enzyme
auto-inhibition.I have found some previously suggested literature by nonmem
users, but all of them were auto-induction cases. Does anyone know any
enzyme auto-inhibition PK model paper published ?
Thanks so much!
Sincerely,
Yuyan Jin
Graduate student
University of Pittsburgh