Re: iNTRAVENOUS VS. INTRA-ARTERIAL SAMPLING
Hi Michael,
You may also look at these references
1. Tuk B, van Gool T,
Danhof M. Mechanism-based pharmacodynamic modeling of the interaction
of
midazolam, bretazenil, and zolpidem with ethanol. J
Pharmacokinet Pharmacodyn. Jun 2002;29(3):235-250.
2. Tuk B, Danhof M,
Mandema JW. The impact of arteriovenous concentration differences on
pharmacodynamic parameter estimates. J
Pharmacokinet Biopharm. Feb 1997;25(1):39-62.
Sebastien
[EMAIL PROTECTED] a écrit :
Hi everyone;
Does anyone have experience modeling data
where some samples were drawn intravenously, while others (sometimes
even
within a given patient) were drawn from an arterial line? There are no
samples drawn simultaneously from both lines, unfortunately.