Re: PK/PD models to describe anti-ancer drug effect on the tumor volume
Here is the Avastin mouse-to-man PK/PD extrapolation:
Efficacy and Concentration-Response of Murine MAb VEGF in Tumor-Bearing Mice
and Extrapolation to Humans.? J. Mordenti, K. Thomsen, H. Chen, Y. G. Meng, V.
Licko, N. Ferrara.? Toxicol. Pathol. 27:14-21, 1999.?
This work was conducted in 1996 and was submitted with the Avastin IND to
support Phase I dose selection/escalation. ?This preclinical study correctly
predicted the marketed dose of Avastin, which was approved in 2004.?? Figures 1
and 9 tell the whole story.?
?
Prediction: 2 mg/kg per week or slightly greater than double the dose every two
weeks.
Approved: 5 mg/kg every two weeks.
- Joyce
PS Email me off line, and I will forward a pdf to anyone who is interested.
Quoted reply history
-----Original Message-----
From: Patrick Zhou <[EMAIL PROTECTED]>
To: [email protected]
Sent: Sun, 6 Jan 2008 11:50 am
Subject: [NMusers] PK/PD models to describe anti-ancer drug effect on the tumor
volume
Dear NMusers,
Does anyone?aware any good published example (or non-public if you are willing
to share)?of modeling the anti-cancer drug effect on the tumor volume in nude
mice model? And how this is normally used in the human dose projection, and any
published work of such?? Please advice. Thank you very much.
?
Patrick
?
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