RE: Bayesian estimation example

-----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Tausif Ahmed Sent: Thursday, April 12, 2007 4:03 AM To: [EMAIL PROTECTED] Subject: RE: [NMusers] Bayesian estimation example Dear Group members, I will make my objective more clear- I have a drug X in which I have information in healthy volunteers with extensive sampling done, single dose (12-14 samples). I have data on appx. 100 volunteers at different dose levels from phase I studies. We also have a data in 16 patients at one dose only, with extensive sampling. Now we have data from 200 patients, with 2-3 blood samples collected from each patient at different doses. It is also seen that the PK changes in patients. What I am interested is that can we use Bayesian estimates, (and I think posthoc estimate from NONMEM, as Yaning mentions) to determine the pharmacokinetics (PK) of the whole population from these 2-3 blood samples collected per patient. Hope it is more clear. I have checked at website- ( http://www.accp1.org/)as suggested by many but could not find any control stream on Bayesian. Can the group help me on this. I thank the experts for giving their comments on the same. Regards Tausif Ahmed Ph.D. Metabolism and Pharmacokinetics Department Ranbaxy Research Lab India -----Original Message----- From: Wang, Yaning [mailto:[EMAIL PROTECTED] Sent: Wednesday, April 11, 2007 8:30 PM To: Nick Holford; Tausif Ahmed Subject: RE: [NMusers] Bayesian estimation example Nick: Tausif may be referring to the posthoc estimate from NONMEM (empirical Bayesian estimate). Yaning -----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Nick Holford Sent: Wednesday, April 11, 2007 10:43 AM To: Tausif Ahmed Cc: [EMAIL PROTECTED] Subject: Re: [NMusers] Bayesian estimation example Tausif, Why do you want to use Bayesian Estimation? If you have only just started to use NONMEM then perhaps you have misunderstood the reasons for using it. It is very rarely needed. Nick > Dear Group members, > > I have recently started using NONMEM for population analysis. > I need you help in understanding Bayesian estimation using NONMEM. > Can any body provide me a sample control stream along with data file (Excel or csv format) and also explain the output. > I use Visual NM to run NONMEM version V. > > Thanking you in anticipation. > > Regards > Tausif Ahmed Ph.D. > Metabolism and Pharmacokinetics Department Ranbaxy Research Lab India -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ (i) The information contained in this e-mail message is intended only for the confidential use of the recipient(s) named above. This message is privileged and confidential. If the reader of this message is not the intended recipient or an agent responsible for delivering it to the intended recipient, you are hereby notified that you have received this document in error and that any review, dissemination, distribution, or copying of this message is strictly prohibited. If you have received this communication in error, please notify us immediately by e-mail, and delete the original message. (ii) The sender confirms that Ranbaxy shall not be responsible if this email message is used for any indecent, unsolicited or illegal purposes, which are in violation of any existing laws and the same shall solely be the responsibility of the sender and that Ranbaxy shall at all times be indemnified of any civil and/ or criminal liabilities or consequences there. -- The information contained in this email message may contain confidential or legally privileged information and is intended solely for the use of the named recipient(s). No confidentiality or privilege is waived or lost by any transmission error. If the reader of this message is not the intended recipient, please immediately delete the e-mail and all copies of it from your system, destroy any hard copies of it and notify the sender either by telephone or return e-mail. Any direct or indirect use, disclosure, distribution, printing, or copying of any part of this message is prohibited. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorized to state them to be the views of XOMA.