Re: AUC and segmented post treatment exposure

Joel, It is certainly possible to get NONMEM to predict the AUC over discrete time segments (assuming you have an adequate parametric model for the concentration) e.g. $SUBR ADVAN6 $MODEL COMP (AUC) COMP (C) COMP (...) ; other compartments if you wish $DES C=A(2)/V1 DADT(1)=C DADT(2)=derivative for PK model DADT(3)=... You can specify in the data file a CMT item of -1 and EVID=2 to reset the AUC compartment at the end of each discrete segment if you want to get the discrete AUC values in the table file. But its also easy to simply subtract the cumulative AUCs in the table file after NONMEM has generated its output. Why do you want to do this? Nick Joel Tärning wrote: > > Dear all, > > I am working with a population model of 100 patients sparsely sampled for 60 > days. It is a 2-compartment model with first order absorption and repeated > oral administration for 3 days. I have some difficulties in finding a code > for estimating AUC for these patients so if anyone could help me that would > save me a lot of time. > > How do I code for AUC in repeated oral dosing for a 2-compartment model? > > Is it possible to code for AUC segments (e.g. 0-20 days and/or 20-40 days > after administration)? > > Thanks > /Joel Tarning > > _____________________________________________ > Joel Tärning, MSc, PhD-student > > Göteborg University > Department of Pharmacology > P.O. Box 431 > 405 30 Göteborg > > Phone: +46 (0) 31 773 3240 > Cellular: +46 (0) 708 514849 > Fax: +46 (0) 31 773 3284 > e-mail: [EMAIL PROTECTED] (mailto:[EMAIL PROTECTED]) -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/