AUC and segmented post treatment exposure

From: Joel Tärning Date: March 27, 2007 technical Source: mail-archive.com
Dear all, I am working with a population model of 100 patients sparsely sampled for 60 days. It is a 2-compartment model with first order absorption and repeated oral administration for 3 days. I have some difficulties in finding a code for estimating AUC for these patients so if anyone could help me that would save me a lot of time. How do I code for AUC in repeated oral dosing for a 2-compartment model? Is it possible to code for AUC segments (e.g. 0-20 days and/or 20-40 days after administration)? Thanks /Joel Tarning _____________________________________________ Joel Tärning, MSc, PhD-student Göteborg University Department of Pharmacology P.O. Box 431 405 30 Göteborg Phone: +46 (0) 31 773 3240 Cellular: +46 (0) 708 514849 Fax: +46 (0) 31 773 3284 e-mail: [EMAIL PROTECTED] (mailto:[EMAIL PROTECTED])
Mar 27, 2007 Joel Tärning AUC and segmented post treatment exposure
Mar 27, 2007 Nick Holford Re: AUC and segmented post treatment exposure