Re: Two dependent variables

Dear all: As to this kind of situation(at least two types of observations or same type of observations from at least two different assay), DO we need change our default objective function? Because I am thinking we will estimate our parameters based on multivariate normal distribution(at least bivariate normal distribution) instead of univariate normal distribution(only one type of observation), so we will have different variance across the observations and we will have covariance issue which is not zero. thanks a lot. Zheng Lu sixth-year graduate student/Smith Lab Department of pharmaceutical sciences College of Pharmacy University of Michigan 428 Church Street, Ann Arbor, MI 48109-1065 Tel: 734-763-7608(o), 734-647-1427(o), 734-647-1437(L) Fax: 734-615-6162(o), 734-763-3438(o) Quoting Nick Holford <n.holford > Hi, > > The 'FLAG' method is a trick that only works with 2 DVs. It is also a > bit inefficient because it requires that both the PK and PD > prediction are calculated but only one is used. > > A more general method uses IF THEN blocks e.g. if you have a data > item DVID with the value 1 with a conc observation and the value 2 > with an effect observation of one type and value of 3 with an effect > observation of a different type: > > CONC=F > IF (DVID.EQ.1) THEN > Y=CONC + ERR(1) > ENDIF > IF (DVID.EQ.2) THEN > Y=EMAX2*CONC/(EC502+CONC) + ERR(2) > ENDIF > IF (DVID.EQ.3) THEN > Y=EMAX3*CONC/(EC503+CONC) + ERR(2) > ENDIF > > Nick > >> >> Yes, you could do a simultaneous fitting with the same >> control stream in NM. For example you could >> have a dummy variable (Flag) that tells NM which likelihood >> function goes with which data. See below >> >> >> >> Flag 0 = PK, Flag 1=PD >> >> >> >> $ERROR >> >> Y=CONC*(1-Flag) + EFF* Flag >> >> >> >> Hopefully this would help. >> >> >> >> Best, >> >> Nidal AL-Huniti, PhD >> >> >> On 1/30/07, navin goyal <navin1180 >> >> Hello, >> I was wondering if I could model two DVs simultaneously >> with the same control stream. >> Like have to equations A=(equation) >> B= (equation) >> >> I have data for two different drugs from same patients >> Could I do it nomem ? and if yes how do I do it? >> >> Any help is appreciated, >> Thanks >> >> >> >> >> > > > > -- > Nick Holford, Dept Pharmacology & Clinical Pharmacology > University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand > email:n.holford > http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ > > >