RE: Two dependent variables

Hi > Hello, > I was wondering if I could model two DVs simultaneously with > the same control stream. > Like have to equations A=(equation) > B= (equation) > > I have data for two different drugs from same patients Could > I do it nomem ? This is somewhat of a large question. Quite simply: yes you can model several drugs simultaneously in NONMEM. If they have the same structural model (e.g. both 2 cpt) then this makes life simpler, but otherwise using the ODE solver ADVANs (6, 9) or the linear algebra solutions (ADVANs 5, 7) you can pretty much do anything you like... Our group has modelled 5 linked drugs simultaneously in NONMEM - I can't see that there's a limit other than on runtimes :-) Cheers Steve -- Professor Stephen Duffull Chair of Clinical Pharmacy School of Pharmacy University of Otago PO Box 913 Dunedin New Zealand E: stephen.duffull P: +64 3 479 5044 F: +64 3 479 7034 Design software: www.winpopt.com