Re: NONMEM

From: "Gastonguay, Marc" marcg@metrumrg.com Subject: Re: [NMusers] NONMEM Date: Thu, 14 Sep 2006 19:12:58 -0400 Steve, I'm curious to learn of examples where FIM-based optimization methods have been useful for achieving designs that minimize bias (#2 in your post below) of parameter estimates. It was my understanding that in order to assess bias of parameter estimates, it is necessary to run batches of MC simulation-estimation cycles and compare estimated values back to a reference "true" value (e.g. simulation model parameter values). Thanks in advance for your insight. Marc Marc R. Gastonguay, Ph.D., President & CEO, Metrum Research Group LLC 2 Tunxis Rd. Suite 112, Tariffville, CT 06081 Direct:860-670-0744, Main:860-735-7043, Fax:860-760-6014 Email:marcg@metrumrg.com, Web:www.metrumrg.com