RE: Error when combining proportional residual error,

From: "Serge Guzy" GUZY@xoma.com Subject: RE: [NMusers] Error when combining proportional residual error, Date: Wed, 02 Aug 2006 Hi Leonid. When you use exponential error model, don't you think NONMEM transform your Concentration data into LogC??? If not, how do you compute the Log-Likelihood?? Of course I think in terms of MCPEM but I cannot understand how you can combine an exponential error with additive and compute a log-likelihood. More specifically, how do you compute the standard deviation that is needed in the computation of the log-likelihood? Log-likelihood= -log(sd)-((Cobs -CPREDICTED)/(SD))2/2 Serge