What are the best studies to combine?

From: musor000@optonline.net Subject: [NMusers] What are the best studies to combine? Date: Thu, 30 Mar 2006 14:33:26 -0500 Hello NONMEM users, We try to combine 2 studies of healthy volunteers (single IV and SC dose) and 1 study of subjects who have a disease (multiple SC doses; concentrations are measured before dosing). NONMEM code is running well. Will such diverse studies lead us to unbiased conclusions? Also, will estimates of Ka from the study of diseased subjects be reliable assuming that concentrations are measured before dosing? Thank you! Pavel