restraining eta code

From: Nele Mueller-Plock Date: March 28, 2006 event Source: cognigencorp.com
From: nplock@zedat.fu-berlin.de Subject: [NMusers] restraining eta code Date: Tue, 28 Mar 2006 11:46:57 +0200 (CEST) Dear all, I have a question regarding a model which restrains all individual parameter estimates to take values between 0 and 1. Im using the following code: PHI=LOG(THETA(7)/(1-THETA(7))) P=EXP(PHI+ETA(4))/(1+EXP(PHI+ETA(4))) My question is: How do I calculate the coefficient of variation for THETA(7), if for example NONMEM gives a value of 0.7 for THETA(7) and and a value of 6.4 for the respective diagonal element of the omega matrix? It was called to my attention that in this case you cannot just take the square root of diagonal element? I would really appreciate your help! Nele

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Mar 28, 2006 Nele Mueller-Plock restraining eta code
Mar 28, 2006 Leonid Gibiansky Re: restraining eta code
Mar 28, 2006 Nele Mueller-Plock Re: restraining eta code
Mar 28, 2006 Mats Karlsson RE: restraining eta code
Mar 28, 2006 Leonid Gibiansky Re: restraining eta code
Mar 28, 2006 Mats Karlsson RE: restraining eta code
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