RE: interoccasion variability

From: "Serge Guzy" GUZY@xoma.com Subject: RE: [NMusers] interoccasion variability Date: Mon, 6 Feb 2006 09:48:28 -0800 That is not my understanding of inter-occasion variability. When you study the same subject on, let say, two different occasions, it is possible to get two different time profile not only due to the measurement noise but also due to a change in the individual PK parameters for that specific individual (sometime due to change in some covariate with time). Usually, you will take the first full time Profile (let say starting day 1, finishing day 10) and will define it as belonging to the first occasion and then the second trial (let say starting day 30, finishing day 40) and will define it as belonging to the second occasion. I do not think that it is appropriate to take one trial data and associate each consecutive day as a different occasion. Serge Guzy President POP-PHARM