covariate selection question
From: Joern Loetsch j.loetsch@em.uni-frankfurt.de
Subject: [NMusers] covariate selection question
Date: Tue, 17 Jan 2006 13:45:24 +0100
Dear NONMEM users,
adding a particular covariate to the basic model does not provide a
significant decrease in -2LL. In the course of model building and
covariate assignment, adding that particular covariate at a later
step did significantly improve -2LL. Deleting that covariate from
the final, full model, does significantly increase the objective
function. Based on -2LL without regarding now the change in IIV,
should that covariate be taken in the final model or not?
Thank you in advance.
Regards
Jrn Ltsch
_______________________________________________________
Prof. Dr. med. Jrn Ltsch
pharmazentrum frankfurt/ZAFES
Institut fr Klinische Pharmakologie Johann Wolfgang Goethe-Universitt Theodor-Stern-Kai 7 D-60590 Frankfurt am Main
Tel.:069-6301-4589
Fax.:069-6301-7636
http://www.klinik.uni-frankfurt.de/zpharm/klin/