Re: PD modeling: What is the most efficient approach to transfer data?

From: Nick Holford Subject: Re: [NMusers] PD modeling: What is the most efficient approach to transfer data? Date: Wed, 21 Dec 2005 07:02:37 +1300 As Bill has pointed out there is a caution one should be especially aware of when doing simultaneous PKPD. If the PD model (including any link between PK and PD such as effect compartment model or turnover model) is badly wrong then it can indeed cause the PK estimates to become biased. This is discussed in the follow on paper by Zheng et al. Zhang L, Beal SL, Sheiner LB. Simultaneous vs. sequential analysis for population PK/PD data II: robustness of methods. J Pharmacokinet Pharmacodyn 2003;30(6):405-16. -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ _______________________________________________________