RE: PD modeling: What is the most efficient approach to transfer data?

From: "Bachman, William (MYD)" bachmanw@iconus.com Subject: RE: [NMusers] PD modeling: What is the most efficient approach to transfer data? Date: Tue, 20 Dec 2005 08:06:04 -0500 The argument made "against" simultaneous PK-PD modeling is that potentially the PD data could drive the PD model (the cart before the horse). Make your own conclusion, just stating the usual argument. The alternative to "transferring data from PK to PD model" is to generate the individualized PK parameters (POSTHOC or FOCE estimates) and include them in the PD data file. Then insert them into the PK model that generates predictions for the PD model. Adding more time points with EVID=2 is the only way I can think of to generate more time points. The only errors you can make are getting the times wrong or not asking for the prediction in the correct CMT.