Re: MM elimination vs dose

From: "Janet R. Wade" janet.wade@exprimo.com Subject: Re: [NMusers] MM elimination vs dose Date: Sat, 1 Oct 2005 09:13:25 +0200 Dear Pete Do you have data from more than one dose level per subject? If so, then your 'issue' reminds me of something I once encountered and where the PK also appeared to be non-linear with respect to dose (to my surprise since there was no previous indication of this). In my case it eventually turned out that the dose effect was no longer significant once I incorporated IOV on CL. Kind regards Janet Janet R Wade Exprimo NV http://www.exprimo.com/ _______________________________________________________