Re: MM elimination vs dose

From: Nick Holford n.holford@auckland.ac.nz Subject: Re: [NMusers] MM elimination vs dose Date: Sat, 01 Oct 2005 05:43:09 +1200 Peter, Non-linear PK can influence other processes apart from elimination. Have you looked for non-linear changes in volume of distribution? You may also want to consider changes in bioavailability with dose -- there could be an issue with the IV formulation as doses increase. I doubt if your drug is eliminated via the skin so why not look for a biologically based allometric scaling function for clearance rather than the discredited BSA scaling method? Finally, IMHO FO is ok for quick and dirty teaching projects but not for serious work... Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556