RE: Simulation vs. actual data

From: "Kowalski, Ken" Ken.Kowalski@pfizer.com Subject: RE: [NMusers] Simulation vs. actual data Date: Fri, July 15, 2005 8:28 am Nick, You wrote: >1. What does M mean with respect to future observations? Your example suggests that M is the number of subjects rather than >the number of observations. But perhaps you mean M is the number of observations conditioned on time and design within a >single trial? Yes, in my example it is the number of observations conditioned on time and dose such that I'm averaging one observation per subject and hence M also refers to the number of subjects (it is our primary sampling unit in population modeling that we want to average over). Note instead of means of observations as my statistic, T, of interest, I could have used another statistic such as a noncompartmental estimate of AUC which is based on n observations (time points) per subject. In which case I have M=12 subject's AUCs that I would average (e.g., geometric mean) as my PPC statistic. >2. Why do you use 'degenerative' instead of 'degenerate'? My apologies, it should be 'degenerate'. Ken