Re: Residuals and INTERACTION for simultaneous PK/PD,impossible?

From: "Nick Holford" n.holford@auckland.ac.nz Subject: Re: [NMusers] Residuals and INTERACTION for simultaneous PK/PD,impossible? Date: Sat, April 16, 2005 1:35 am Eleveld, I agree with Yaning that it should make no difference if you use INTERACTION with a homoscedastic residual error model. I like his elegant explanation of how NONMEM is trying to solve the problem. It seems to me that INTERACTION should be a default option for METHOD=CONDITIONAL. I don't know how it can adversely effect the result except possibly for a bit of extra computation time. The current default (no INTERACTION) is an unfortunate pitfall if you are either unaware of this issue of simply overlook it in the excitement of building a new model. Nick _______________________________________________________