RE: Simulated PD value at time zero

From: "AbuTarif, Malaz" malaz.abutarif@spcorp.com Subject: RE: [NMusers] Simulated PD value at time zero Date: Tue, February 1, 2005 3:55 pm Dear, I think this is similar to what Max was asking earlier in the week [NMusers] Indirect response PD model. Without the drug, baseline PD is basically a steady state situation. NonMem does not know that. So, the solution to your problem is exactly the solution to Max's problem, I think. Initialize the effect or PD compartment with a bolus "PD dose" so it starts from ss conditions level (baseline), or define the effect compartment as a ss situation. Malaz Malaz A. AbuTarif, B.Sc. (Pharmacy), Ph.D., G.C.P.M. Associate Principal Scientist Schering-Plough Research Institute 2015 Galloping Hill Rd., K15-2-2650 Kenilworth, NJ 07033 Tel: (908) 740-3835, Fax: (908) 740-2916 malaz.abutarif@spcorp.com _______________________________________________________