Re: Model building question

From: "Nick Holford" n.holford@auckland.ac.nz Subject: Re: [NMusers] Model building question Date: Mon, February 28, 2005 1:40 pm Kai, As a general modelling philosophy you should always consider estimating BOV if you have repeated occasions. The alternative that BOV is 0 is a very unlikely assumption. In your specific case you may wish to consider both a systematic as well as a random change in parameters. You could try estimating both the mean change in each parameter relative to the first occasion and on top of that estimate the BOV as the true random differences between the occasions. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/