RE: Model building question

From: "Bhattaram, Atul" BhattaramA@cder.fda.gov Subject: RE: [NMusers] Model building question Date: Mon, February 28, 2005 8:13 am Hello Kai You could do the following: 1. Look at the concentration-time profile for the mean data and a couple of individuals in the 2 occasions. 2. Develop a base model without occasion variability. Again take a look at the data and the predicted values. 3. Add occasion variability if you think it is important and then compare the decrease in variance before and after. During the model building process you would have identify if you want to explain your data using a 'statistical' model or a 'mechanistic' model. The former would only describe the data, but would not be of much help in predictive purposes. For the latter you will need more data to 'qualify' your model. Venkatesh Atul Bhattaram Pharmacometrics CDER/OCPB/FDA