PD lag time in $DES

From: "Jim Jiang" Subject: [NMusers] PD lag time in $DES Date: Wed, November 17, 2004 7:02 pm Dear All, I am using NONMEM to estimate PKPD parameters simultaneously. But the drug I am studying has indirect PD response. I would like to know how to estimate PD lag-time while using differential equation. Many Thanks Jim Dr. Jim Xuemin Jiang N415, Faculty of Pharmacy, Building A15, The University of Sydney, NSW, 2006 Telephone: 61 2 90365025 Fax: 61 2 93514391 Email: xuemin@pharm.usyd.edu.au