RE: Negative values in 95%CI on ETAs

From: "Bhattaram, Atul" BhattaramA@cder.fda.gov Subject: RE: [NMusers] Negative values in 95%CI on ETAs Date: Tue, November 16, 2004 2:43 pm Hello Manoj A couple of quick comments: 1. It is better to parameterize models in terms of CL, V, Q, VSS or V(peripheral) instead of the parameterization you have chosen. 2. You could try different values of Ka and check how it influences the results. 3. What is the estimation procedure you are using? Venkatesh Atul Bhattaram Pharmacometrics DPE-1, OCPB CDER, FDA.