RE: Decrease in OFV with a fixed effect

From:"Vanapalli_Sreenivasa" Vanapalli_Sreenivasa@allergan.com Subject: RE: [NMusers] Decrease in OFV with a fixed effect Date: Tue, August 24, 2004 11:05 am Peter, Looks like you've fixed THETA(2), which was V1 in the first model and your assumption of fixing V1 was right. However, you have incorporated other variables in the equation in the second model which is 'body weight' and also THETA(6). Now you are computing V1 based on all these parameters not just with 'fixed THETA(2)'. I don't see V1 fixed anymore with all these new variables into equation. With changing body weights the fit looks much better (not fixed) resulting in decreased OBJ value. I may be wrong with my explanation. Regards, Sreenivasa Rao Vanapalli, Ph.D. Scientist, Clinical Pharmacokinetics Allergan Inc. 2525 Dupont Drive, RD2-2B Irvine, CA 92623-9534 E-mail: vanapalli_sreenivasa@allergan.com Phone: (714) 246-4325 Fax: (714) 246-5538