RE: PK models for rich and sparse sampling

From: Steve Duffull sduffull@pharmacy.uq.edu.au Subject: RE: [NMusers] PK models for rich and sparse sampling Date: Tue, June 1, 2004 6:12 pm Mark... Re: Wishart... > once you get beyond about 5 DF, the result isn't very sensitive to the choice (I usually use about 20) We generally simulate from the Wishart and compare nonparametric intervals (say 25th and 75th percentiles) on the simulated OMEGA's vs what we think seems reasonable (e.g. from prior analyses). The choice of dof with the Wishart is also linked to its dimensionality - so a dof of 5 has a different meaning for a OMEGA matrix of rank of 2 vs one with a rank of 5. Steve ========================================Stephen Duffull School of Pharmacy University of Queensland Brisbane 4072 Australia Tel +61 7 3365 8808 Fax +61 7 3365 1688 University Provider Number: 00025B Email: sduffull@pharmacy.uq.edu.au www: http://www.uq.edu.au/pharmacy/sduffull/duffull.htm PFIM: http://www.uq.edu.au/pharmacy/sduffull/pfim.htm MCMC PK example: http://www.uq.edu.au/pharmacy/sduffull/MCMC_eg.htm