RE: RE: steady state dosing

From: Bachman, William (MYD) bachmanw@iconus.com Subject: RE: [NMusers] RE: steady state dosing Date: Tue, April 13, 2004 8:42 am As always, there is more than one day to do this. What I would do is: 1. code steady state dosing representing the bulk of the dosing during the four weeks with one dose event record (SS=1, II=12) and coded at a time prior to the 22:00 dose. 10:00 on the same day as the 22:00 dose seems plausible. On second thought, just coding the 22:00 dose as a steady state event (SS=1, II=12) should be sufficiently accurate. 2. code the dose taken at 22:00 as a non-steady state dose (SS=0, II=0) as accurately as possible (with respect to time). 3. code the observation at 8:00 as accurately as possible (with respect to time). 4. code any other doses and observations on the same day (as the first observation) as non-steady state events. e.g. the dose at 8:05 and any other samples taken at their respective times. 5. if another long interval occurs between sampling, code in a similar manner: steady state dose to maintain the levels at steady state, then non-steady state dose events during the sampling period if the doses are not given at regular intervals and use accurate times for these doses and samples. Bill _______________________________________________________