RE: no. of dummy points affect simulation and estimation results

From: phil.lowe@pharma.novartis.com Subject: RE:[NMusers] no. of dummy points affect simulation and estimation results Date: Tue, April 20, 2004 6:14 am Dear Sandra, Although interested in the responses from nmusers on the technical fixes for the sampling times, with your PD system, is there a way to calculate what the steady-state should be from time zero and set this explicitly? This would avoid having to allow time for the system to come to equilibrium. I copy below some code I was working on over a weekend to explore the possibility of estimating PD turnover rates for a linked PD system. In this example, the starting conditions for each of the PD variables is set using the fraction, F, and setting a dose of 1 at t=0 in the data file. I have not got any further as yet to explore other interconnection possibilities than a linear chain. A bit of algebra would be required to calculate the initial conditions for more complex networks. Best regards, Phil. Philip Lowe PhD Modelling & Systems Biology Clinical Development & medical Affairs Novartis Pharmaceuticals AG 4002 Basel Switzerland