RE: no. of dummy points affect simulation and estimation results

From: Pascal Girard Date: April 20, 2004 technical Source: cognigencorp.com
From: GIRARD PASCAL PASCAL.GIRARD@adm.univ-lyon1.fr Subject: RE: [NMusers] no. of dummy points affect simulation and estimation results Date: Tue, April 20, 2004 5:37 am Sandra, Here are 2 more efficient ways to initialize your compartment, which avoid defining dummy times: 1) either put a steady state (SS=1) dose at time 0 with a correct value for AMT producing the initial correct value in the given compartment, or 2) put a dummy unit dose of 1 at time 0, as you did, and set F1, F2, ..., F5 the bioavailability parameters for each compartment to their respective initial values. Here is a simple illustration for an indirect action model. $MODEL COMP=(CENTRAL) ; Compartment 1 COMP=(RESP) ; Compartment 1 $PK KIN=THETA(1) KOUT=THETA(2) BASE=KIN/KOUT ; Baseline is the ratio of Kin and Kout ; INITIALISATION OF RESPONSE COMPARTMENT ; NEED to have AMT=1 at TIME=0 in compartment 2 F2=BASE Best regards, Pascal Girard

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Apr 20, 2004 Sandra Visser no. of dummy points affect simulation and estimation results
Apr 20, 2004 Nick Holford RE: no. of dummy points affect simulation and estimation results
Apr 20, 2004 Pascal Girard RE: no. of dummy points affect simulation and estimation results
Apr 20, 2004 Phil Lowe RE: no. of dummy points affect simulation and estimation results
Apr 20, 2004 Pavel Kovalenko RE: no. of dummy points affect simulation and estimation results
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