Re: Two simple questions

From: n.holford@auckland.ac.nz Subject: Re: [NMusers] Two simple questions Date: 10/9/2003 6:12 PM >> >> I have 2 questions I hope somebody can help me with: >> >> - I am trying to do some simulations and need to fix a parameter to a value >> greater than 999999 (which seems to be the maximum value in NONMEM). Is >> there any way of getting around this limit? >> $THETA 1 ; BIG / 1.0D10 $PK BIG = 1.0D10 * THETA(1) CL=BIG*EXP(ETA(1) >> - AMD has now introduced a new generation of processors for ordinary >> desktop, Athlon 64. This processor can handle data in chunks of 64 instead >> 32. This processor is also able to take advantage of higher RAM. Machines >> with Athlon 64 can still run programs written for the 32 bit chips. Will >> NONMEM (Fortran?) be faster under this new processor type? >> NONMEM will probably not care (but who knows the gremlins that may lurk inside that assume certain word sizes?). The critical thing will be the compiler. If you can find a compiler that generates code for 64 bit AMD then NONMEM should be able to use it. The only 64 bit f77 compiler I know of is the Intel compiler but I think it only targets the Itanium 64 bit Intel CPUs (not surprisingly). Whether 64 bit is faster than 32 bit is a matter for experiment. -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/ _______________________________________________________