Simulating large number of samples

From: tgordi@buffalo.edu Subject: [NMusers] Simulating large number of samples Date: 8/26/2003 9:54 AM Dear all, I am trying to perform a simulation of both PK and PD using NONMEM. When simulating an extensive sampling (1 individual, around 90 PK and 90 PD time-points within 7 days) I get the following message: 0TOT NO. OF PRED-DEFINED RECS IN BUFFER 6 IS LESS THAN NO. OF DATA RECS WITH SOME INDIVIDUAL SEE INSTALLATION GUIDE Cutting down the file to 20 PK and 20 PD time-points (within 2 days) results in successful simulation. It seems to me that there is some default setting that does not allow for too many data-points to be simulated. Is there any remedy for this that does not involve cutting down the number of generated data-points? Thanks! Toufigh Gordi