RE: Model estimates based on 1 sample per subject

From: GUZY@xoma.com Subject: RE: [NMusers] Model estimates based on 1 sample per subject Date: 8/19/2003 4:27 PM I am surprised that you could evaluate 2 parameters with one single data point using Winnonlin (does not do a population fit). Using Population modeling, I think that the same time point for each rat (30 minutes) can easily make the problem non identifiable. If it is identifiable, you need anyway to fix the intraindividual variance to some value. Serge Guzy President POP-PHARM Head of Preclinical Statistics and Pharmacometrics, Xoma