Re: RE: ROUNDING ERRORS (ERROR=134)

From:"Jerry Zhao" Subject:Re: RE: [NMusers] ROUNDING ERRORS (ERROR=134) Date:Tue, 13 May 2003 13:35:33 -0800 Dear Dr. Bhattaram, Thank you for your repsonse. The model is identifiable, because the fraction of parent drug being converted to metabolite is known (40%). The volume of metabolite distribution can be uniquely estimated. I was trying specifically to look for the inter-parameter covariance in this exercise by asking NONMEM to estimate the off-diagonal elements (OMEGA BLOCK(6)). I have already got fine results with only the diagonal elements OMEGA being estimated. With the above questions answered. Can you think of any reason for the ROUNDING ERROR? In fact, could you shed some light on what causes this error? Thank you. Jeri Sottos