RE: ROUNDING ERRORS (ERROR=134)

From: "Bhattaram, Atul" Subject: RE: [NMusers] ROUNDING ERRORS (ERROR=134) Date:Tue, 13 May 2003 14:34:07 -0400 Hello Zhao You might want to do an identifiability analysis for your model. In case you dont have any prior estimates for the metabolite administered seperately you might want to fix its V to say 10 times the volume for the parent drug. Also why are you interested in all offdiagonal elements (OMEGA BLOCK (6))? You should perhaps reduce the dimensionality of your model. You will find this reference useful: An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine. Evans ND, Godfrey KR, Chapman MJ, Chappell MJ, Aarons L, Duffull SB. J Pharmacokinet Biopharm 2001 Feb;28(1):93-105 Venkatesh Atul Bhattaram CDER, FDA.