RE: Mixture models in NONMEM

From:"Sam Liao" Subject: RE: [NMusers] Mixture models in NONMEM Date: Thu, 17 Apr 2003 19:14:20 -0400 Hi Rajesh: The problem may not be the mixture model. The two-compartment oral model itself is very sensitive to the initial estimates. You need to find ways to get good initial estimates. Also try to model F1 with the mixture model because the first-pass metabolism may be affected by genotype. We may be able to help you further if you can share your control file. Best regards, Sam Liao, Ph.D. PharMax Research 20 Second Street, PO Box 1809, Jersey City, NJ 07302 phone: 201-7983202 efax: 1-720-2946783 _______________________________________________________