Re:Repeat administration with varying dose interval

From:sophie Callies Subject:[NMusers] Re:Repeat administration with varying dose interval Date:Wed, 22 Jan 2003 14:26:40 +0100 (CET) Dear Michael My suggestion to your problem would be to put in the data set for each patients all the dose record with their respective time calculated from the first dose given. This will take into account to problem of the variability in the dose interval. Then to had a event identification column EVID (see nonmem manual) which would be equal to : 4 for when time = 0 (first dose of each patient) 1 for the other dose records with time different of 0 (this reset the dose comparmtent whitout reseting to 0 the amount in the observation compartment) 0 for the observation record The only issue with my suggestion is the number of records per patient allowed by NONMEM. I hope that my suggestion will help Sophie Callies