Repeat administration with varying dose interval

From:michael.looby@pharma.novartis.com Subject:[NMusers] Repeat administration with varying dose interval Date:Wed, 22 Jan 2003 11:44:04 +0100 Dear NMusers We have a problem that involves repeated administration of a formulation that is released by a first order process, but this absorption process is completely terminated just prior to administration of the next dose. Furthermore, the inter-dose interval is not constant. How can we code this within NONMEM? It is our understanding that this kind of problem would involve resetting the dosing compartment prior to each subsequent dose in a mutliple dose setting without resetting the observation compartment. We would be grateful for your input. Kind regards Mick