RE: Oral pharmacokinetics sparse (no absorption phase)

From: "Bachman, William" Subject: RE: [NMusers] Oral pharmacokinetics sparse (no absorption phase) Date: Wed, 8 May 2002 11:55:11 -0400 Atul, One might try a formal sensitivity test using a range of fixed ka's (you've done this in a limited informal way already). 1. pick the range and interval of fixed ka values to test and make the runs 2. compare the effect of changing ka on the remaining parameter estimates and their standard errors, goodness of fit (plots, obj. fcn values, and variance estimates) (In all cases assure yourself you have a global minimum, successful $COV step, etc.) 3. pick the "best" overall fixed ka and live with it. Bill *******