RE: Error message..

From: Kenneth Kowalski Date: March 07, 2002 technical Source: cognigencorp.com
From:"Kowalski, Ken" Subject:RE: [NMusers] Error message.. Date:Thu, March 7, 2002 8:22 am Emily, The R matrix singular condition is an indication that your model is over-parameterized, i.e., an infinite set of parameter values in Theta, Omega and Sigma can result in the same value of the Objective Function. I suggest that you re-check the coding of your model to verify that it is correct and what you intended. If that is fine, you may have to reduce your model. If you can provide the control stream as Sam suggests I'm sure one or more NMUSERs will be happy to provide you some suggestions on modifying your model. Regarding the T matrix I could not find any description of it in the NONMEM user's guides. Does anyone out there know? I believe it is only reported when the R matrix singular condition arises and presumably is a diagnostic that can help determine the nature of the singularity. Ken
Mar 07, 2002 Emily Error message..
Mar 07, 2002 Sam Liao RE: Error message..
Mar 07, 2002 Kenneth Kowalski RE: Error message..
Mar 07, 2002 Amir A. Tahami Re: Error message..
Mar 07, 2002 Thomas Ludden T Matrix
Mar 08, 2002 Emily Error message (continued..)
Mar 08, 2002 Nick Holford Re: Error message (continued..)